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For most applications in
organic synthesis, peptides included, aminoacids
need a temporary protection of their functional groups.
Most protection methods make use of phosgene derivatives
such as activated carbonates or chloroformates: this gives
a competitive advantage to ISOCHEM
who proposes an extensive choice af protected aminoacids,
either N-protected:
- N-benzyloxycarbonyl aminoacids ( N-Cbz-aminoacids
)
- N-tertButyloxycarbonyl aminoacids ( N-Boc-aminoacids
)
- N-Fluorenylmethoxycarbonyl aminoacids ( N-Fmoc-aminoacids
)
or O-protected:
- Methyl, benzyl, cyclohexyl, tertButyl or allyl esters
- Benzyl, methyl or tertButyl ethers of hydroxyaminoacids
A more specific family of derivatives is obtained by direct
phosgenation of aminoacids and ISOCHEM
developed a competitive edge for the production of N-carboxyanhydrides
( NCAs or Leuchs's anhydrides ) and their urethane stabilized
forms, UNCAs, which are outstanding tools for Peptide
chemistryand other transformations of aminoacids.
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